Dr. Bernice Grafstein's paper on the mechanism of spreading depression.
نویسنده
چکیده
ALBERT EINSTEIN is sometimes credited with the dictum that no important new idea will be accepted unless at first it is thought crazy. Certainly none of the reviewers thought this of Dr. Bernice Grafstein’s paper in 1956 (4), in which she established the fundamentals of the mechanism of cortical spreading depression (CSD), but it seems there were “sharp differences of opinion” about her interpretation of her data. Grafstein’s conclusion—that propagation of CSD depends on the liberation of potassium ions from depolarized neurons— has been challenged by a model centered instead on glutamate release, but in nearly 50 years it has never been refuted. In the same paper, Grafstein (Fig. 1) also demonstrated that recovery from spreading depression is an oxidative, energy-dependent process, and this conclusion is now central to concepts of the way in which acute brain injury evolves, both in experimental models and now increasingly in patients receiving neurocritical care.
منابع مشابه
Electrical prodromals of spreading depression void Grafstein's potassium hypothesis.
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عنوان ژورنال:
- Journal of neurophysiology
دوره 94 1 شماره
صفحات -
تاریخ انتشار 2005